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A volunteer subject with no known significant health problems who participates in research to test a new drug, device or intervention. These volunteers are recruited to serve as controls for patient groups. Healthy volunteers receive the same test, procedure, or drug the patient group receives.

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During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Search Results 421-430 of 568 for sleep

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  1. The Effects of Aortic Valve Replacement on Sleep Disordered Breathing, Heart Rate Variability and Ventricular Ectopy Burden in Patients with Severe Aortic Stenosis

    Rochester, MN

  2. Changes in Sleep and Symptoms in People With Inflammatory Bowel Disease Undergoing Ostomy Surgery

    Scottsdale/Phoenix, AZ, Rochester, MN

  3. Sleep Deprivation Effect on Heart Rate Variability and Recovery Status in Active-Duty Firefighters

    La Crosse, WI

  4. A Study to Evaluate Sleep Timing and Duration in Patients with Postural Orthostatic Tachycardia Syndrome

    Rochester, MN

  5. Effect of Alcohol on Home Sleep Apnea Testing Using Peripheral Arterial Tone

    Scottsdale/Phoenix, AZ

  6. Interviews Assessing Mood and Eating Behavior among Participants in the Physiologic Effects of Sleep Restriction

    Rochester, MN

  7. Interviews Assessing Mood and Eating Behavior Among Participants in the Sleep Restriction and Obesity Study IRB 11-007272

    Rochester, MN

  8. Electrophysiologic and Biosensor Signal Analysis of Patients and Controls

    Rochester, MN

  9. Sleep Patterns as Predictive Markers of Hospitalization or Death Due to Cardiovascular Disease in Elderly Patients

    Rochester, MN

  10. Association of RLS/WED and Ferritin Level in Bariatric Surgery Patients

    Rochester, MN

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