Clinical Trials

The purpose of this study is to describe the complications that occur during a shoulder arthroplasty surgery and the outcomes after, due to the altered anatomy or damage from a previous surgery to fix a fracture.

Tightrope arthroplasty and ligament reconstruction with tendon interposition (LRTI) are both acceptable treatment options for painful arthritis at the thumb carpometacarpal joint. Advocates of the tightrope arthroplasty often cite early postoperative mobilization as a benefit to using this technique over alternative procedures. However, early postoperative rehabilitation protocols are used following the LRTI technique at our institution as well. Our study aims to clarify whether early mobilization following LRTI results in different short-term outcomes compared to tightrope arthroplasty.

The purpose of this study is to determine the sensitivity, specificity, positive and negative predictive values of molecular detection of microorganisms, detection of microbial proteins and antibodies against microorganisms, and inflammatory markers (e.g., leukocyte esterase, CRP) in synovial fluid for the diagnosis of prosthetic joint infection (PJI).

The purpose of this study is to find out whether knee joint fluid (synovial fluid) contains substances which may interfere with laboratory tests not normally done on synovial fluid. 

The correlation between lymphedema and shoulder arthroplasty will be analyzed using medical records for all patients that came to the Mayo Clinic with a diagnosis of lymphedema within the time period of 1979-2016.

We will use multiple variables to analyze the associations between lymphedema and multiple other factors, including infection, recurrence of disease, implant failure, etc.

Of the three most commonly/routinely performed surgical technique of patellar resection during total knee arthroplasty performed at the Mayo Clinic, which results in the most symmetrically resected patella (knee-cap)?

The aim of this study is to evaluate the incidence of infrapatellar branch of the saphenous nerve encounters during the standard medial parapatellar approach to the knee during arthroplasty.

The purpose of this study is to:

• Determine patient reported outcomes following total hip arthroplasty based on surgical approach.
• Determine if the Forgotten Joint Score (FJS)-12 has superior capability to discriminate outcomes in patients with THA compared to the modified Harris Hip Score (mHHS).

The purpose of this study is to determine if  medically contained (MC) total knee arthoplasty (TKA) achieves similar patient satisfaction at 1-year follow-up compared to posterior stabilized (PS) TKA.

The study aim is to conduct a clinical research investigation to compare two alignment techniques used in contemporary total knee arthroplasty by means of a prospective non-randomized clinical trial. The two alignment techniques are Kinematic Alignment (KA) and Mechanical Alignment (MA).

This study seeks to evaluate the difference in clinical, radiographic and functional outcomes between ultracongruent, medial pivot and posterior stabilized TKA bearings in a retrospective cohort.

Total knee arthroplasty (TKA) is a reliable and durable procedure. In contemporary TKAs, there are mutliple bearing options, the benefits of which remain unclear.

The purpose of this study is to analyze all of the variables (eg implant types, duration between procedures, etc) and the effect each had on the long-term outcomes of total wrist arthroplasty.

The purpose of this study is to learn the effects of synovial fluid, a clear thick joint lubricant, on joint cartilage tissue and the development of osteoarthritis

This study aims to investigate whether administration of vancomycin intravenously via a Bier block, typically a method for providing regional anesthesia in the upper extremity, leads to higher soft tissue and bone antibiotic concentrations compared to routine intravenous administration.  Higher tissue concentrations could be desirable for prophylaxis in complex upper extremity reconstruction, or for treatment of difficult infections.

This research study is being done to find out if there is any correlation between metal ion levels (cobalt and chromium) in the fluid around your hip, and those that are found in your blood. One factor that may cause failure of a total hip arthroplasty is an elevated level of these ions around the hip.

This project is focused on understanding the risk of cognitive impairment and dementia in total hip and total knee arthroplasty patients. It involves 4 aims:

AIM 1. To determine the risk of dementia in patients with TJA. Using the REP, we will identify a population-based cohort of 9,000 TJA patients and a matched cohort of 9,000 non-TJA patients. The overall risk of dementia and subtypes will be compared between the two cohorts.

AIM 2. To determine cognitive function and neuroimaging measures in patients with TJA. Within the existing data from the MCSA cohort (IRB: 14-004401), we ...

The purpose of this study is to evaluate the orthopedic patients’ perspective on the use of indwelling foley catheters.

The purpose of the study is to determine the survivorship, clinical outcomes, and mechanisms of failure associated with total hip and knee arthroplasty in patients with osteogenesis imperfecta.

The purpose of this study is to determine is the Stablyx ® CMC arthroplasty system provides acceptable outcomes for patients.

The primary aims of this study are to determine whether extended oral prophylactic antibiotics after primary total joint arthropasty (TJA) decreases the incidence of periprosthetic joint infection (PJI) in a high-risk patient population, and to determine whether extended oral prophylactic antibiotics after primary TJA decreases the incidence of surgical wound complications in a high-risk patient population.

The aim of this protocol is to determine clinical, functional, radiographic, and survival outcomes in patients undergoing an uncemented reverse total shoulder arthroplasty for a proximal humerus fracture.

The objective of the study is a multi-center prospective registry to collect clinical outcomes of  knee arthroplasty.

The purposes of this study are to determine:  the risk of cardiomyopathy and heart failure, and cardiac structure and function in patients with THA and TKA. This study will also determine the association between serum and/or synovial fluid metal ion levels with cardiac structure and function in 100 prospectively-recruited THA and TJA patients.

This study is being conducted to determine gene and protein expression profiles (i.e. which genes and proteins are turned off and on) of those with a possibility of developing osteolysis, infection, arthrofibrosis or metallosis of their THA/TKA.

The purpose of this study is to explore the clinical impact of pain management education using a mobile web-based education delivery system compared to standard education delivery. This study seeks to understand the difference between two different education delivery methodologies and the effect on the postoperative pain experience, including participation in treatment plan, knowledge, pain outcomes, and opioid requirements in patients undergoing major hip (THA) and knee (TKA) arthroplasty. It is hypothesized that a real-time, interactive, mobile education system will demonstrate improved pain associated outcomes and higher patient participation when compared to the current standard education delivery method.

The purpose of the study is a multi-center prospective registry to collect clinical outcomes of anatomic and reverse total shoulder arthroplasty.

The purpose of this study is to evaluate the clinical outcomes, survivorship, and complications of HIV-positive patients undergoing total hip or total knee arthroplasty at the Mayo Clinic in the past 20 years.

The purpose of this study is to compare validated clinical and functional outcomes between patients who acutely present with 3- and 4-part Proximal Humerus Fractures (PHFs) treated nonoperatively or with rTSA. We hypothesize that in displaced 3- and 4-part proximal humerus fractures, rTSA will have better pain relief and functional outcomes than nonoperative treatment.

The purpose of this study is to to assess the clinical and radiographic outcomes of patients who have undergone shoulder arthroplasty.

The purpose of this study is to evaluate the outcomes of patients who received an Allograft-Prosthesis Composite for Revision of Catastrophic Failure of Ulnar Component of Total Elbow Arthroplasty.