Clinical Trials

The purpose of this study is to better understand how the heart’s health and function is affected by HIV infection and use of active antiretroviral therapy.

Given the importance of healthy lifestyle practices to cardiovascular disease (CVD) prevention and the utility of church-based interventions in African-American adults, the investigators developed a theory-informed, strategically-planned, health and wellness intervention with Rochester, Minnesota (MN) and Twin Cities area (Minneapolis, St. Paul, MN) churches with predominately African-American congregations. The objective of the study was to partner with churches to implement a multi-component, health education program through the use of core educational sessions delivered through a digital-application accessible on demand via interactive access on computer tablets and the Internet. The overarching goal was to increase the awareness and critical importance of ...

The purpose of this study is to apply a community-based participatory research (CBPR) approach to rigorously refine and test the feasibility and preliminary effectiveness of our existing cardiovascular (CV) health and wellness digital application (app) prototype to improve CV health according to the American Heart Association Life’s Simple 7 (LS7) framework among African-American (AA) adults within faith communities.

The purpose of this study is to determine the effectiveness of intensive, guideline-directed, preventative therapies on cardiovascular disease in the homeless population to help develop an appropriate care model for preventing and treating CVD in the homeless.

The purpose of this study is to understand the extent of routine cardiovascular screening in patients with rheumatoid arthritis to improve management of their cardiovascular disease and optimize cardiovascular preventive strategies for this group of patients.

The purpose of this studyis to determine the effectiveness of an AI-enabled ECG to detect cardiomyopathy and its impact on clinical outcomes in a predominantly Black obstetric population in Nigeria

The primary purpose of this study is to determine if there are significant differences with respect to baseline between those randomized to CGo and standard-of-care versus standard-of-care alone after completing 12-weeks of therapy in terms of peripheral endothelial function measured by EndoPAT.

The objectives of this study are to measure psychosocial cardiac distress* in Latinx/Latino/Hispanic (L/H) women with a history of an acute coronary syndrome (ACS), as well as those with traditional cardiovascular risk factors, but no ACS (diabetes, hypercholesterolemia, obesity, and hypertension), to examine the effects a composite measure for psychosocial cardiac distress has on health-related quality of life (QoL) on women with ACS and those with cardiovascular risk factors and to examine the impact acculturation, acculturative stress, perceived discrimination, and familism can have on the association between cardiac distress and QoL on L/H women with ACS and cardiovascular risk factors. 

*Cardiac distress is defined as ...

The ultimate goal of our partnership with local African-American churches is to implement an effective, multi-component intervention to increase awareness of the critical importance of healthy lifestyle in the prevention of cardiovascular disease (CVD). We will utilize the American Heart Association (AHA) prevention strategy, "Life's Simple 7" to address the major risk factors for CVD: diet, smoking, physical inactivity, hypertension, diabetes, cholesterol and obesity in order to improve overall cardiovascular health. Our main strategy consists of a community-based participatory research approach that involves focus groups to assess participant knowledge and beliefs about CVD risk factors prior to program initiation. We ...

The purpose of this study is to evaluate the outcomes of a community placed atrial fibrillation (AF) screening and education program

The purpose of this study is:

• Specific Aim 1:  To determine the prevalence of obesity, cardiometabolic risk factors and mental health diagnoses among transgender children and adolescents evaluated at the Mayo clinic Transgender and Intersex Specialty Care Clinic (TISCC)
• Specific Aim 2:  To measure adipokines related to energy homeostasis and insulin sensitivity in transgender children and adolescents and compare with those in cisgender age and gender matched controls.

The purpose of this research study is to learn more about the risks to heart health in children and young adults with nephrotic syndrome. Nephrotic syndrome is a rare kidney condition that can affect children. They may be more likely to develop heart disease, high blood pressure and high cholesterol. We hope that the results of this study will help us to learn which tests should be used to determine which patients are most at risk for developing these illnesses.

The purpose of this study is to evaluate the effectiveness of adding epanova to statin therapy for lowering major adverse cardiovascular events in high cardiovascular risk patients with hypertriglyceridemia.

The purpose of this study is to understand the logistical aspects and the barriers that athletes with cardiovascular disease have faced in the process of returning to play, to understand the decision-making process that occurs among athletes, their families, medical professionals, and the school/club administration in choosing to return to the field, and to understand the contingency/emergency plans in the athletes who returned to play.

The purpose of this study is to identify implementation approaches that foster routine, high-quality SDM about CV prevention in the care of at-risk people.

The purpose of this study is to investigate the overnight hemodynamic changes and impact of energy drinks on sleep in young people. 

The purpose of this study is to determine if an initial invasive strategy of cardiac catheterization and optimal revascularization with optimal medical therapy is the best management strategy compared with an initial conservative strategy of optimal medical therapy alone for higher-risk patients with stable ischemic heart disease.

The purpose of this study is to explore, through surveys of providers and patients, the frequency and nature of shared decision making aspects in the cardiovascular care of cancer patients seen in the cardio-oncology clinic referred by an oncology provider.

The purpose of this study is to evaluate the ability of a range of new, easy to use, proprietary food based products to affect cardiovascular disease (CVD) risk factors by positively impacting blood cholesterol levels in statin intolerant and/or statin unwilling participants.

The aim of the study is to establish a correlation of the individual’s genetic risk through the polygenic risk score in young patients with the presence of coronary atherosclerosis diagnosed by CT coronary calcium score.

The purpose of the ISCHEMIA-CKD trial is to determine the best management strategy for patients with stable ischemic heart disease (SIHD), at least moderate ischemia and advanced chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] <30 or on dialysis). This is a multicenter randomized controlled trial with a target randomization of ~1000 patients with advanced CKD and at least moderate ischemia on stress testing. Participants will be assigned at random to a routine invasive strategy (INV) with cardiac catheterization (cath) followed by revascularization plus optimal medical therapy (OMT) or to a conservative strategy (CON) of OMT, with cath and ...

A multicenter prospective randomized clinical trial testing the hypothesis that a patient-centered actigraphy intervention will result in increased physical activity for frail older adults increase during the critical first 30 days after a cardiovascular hospitalization.

The purpose of this study is to see how usefull will the Heart SMART program be in moderate or high stress patients who are referred to the Women's Heart and Preventive Cardiology clinics at Mayo Clinic.

The purpose of this study is to compare the cardiovascular function in young women (<46 years)="" following="" bilateral="" oophorectomy="" who="" are="" treated="" with="" either="" the="" standard="" dose="" of="" estradiol="" (100="" mcg="" transdermal="" patch="" or="" equivalent="" oral="" dose)="" or="" titrated="" estradiol="" dosing="" to="" achieve="" average="" premenopausal="" estradiol="" level="" (80-120="" pg/ml),="" to="" characterize="" the="" relationship="" between="" the="" serum="" estradiol="" level="" and="" cardiovascular="" function="" in="" young="" women=""><46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent ... years)="" on="" estradiol="" replacement="" after="" bilateral="" oophorectomy,="" and="" to="" compare="" the="" body="" composition="" in="" young="" women="" following="" bilateral="" oophorectomy="" who="" are="" treated="" with="" either="" the="" standard="" dose="" of="" estradiol="" (100="" mcg="" transdermal="" patch="" or="" equivalent="" ...="">

The purpose of this study is to characterize TRPC6 risk variants for doxorubicin-related cardiotoxicity in prospectively collected samples from breast cancer patients.   

Breast cancer patients are more than three times at risk for developing congestive heart failure (CHF), compared with patients who did not have cancer. The increased risk of HF is observed as early as one year from diagnosis of cancer and overall, 7% of patients develop CHF (median follow-up 8.5 years) 

The purpose of this study is to collect and correlate the data from various cardiovascular risk asessments to successfully measure the risk of heart toxicity in patients receiving chemotherapy for breast cancer.

The purpose of this study is to evaluate different strategies of cardiovascular therapy with Carvedilol, aiming to reduce the incidence of left ventricular ejection fraction (LVEF) decline and heart failure (HF) in patients undergoing curative intent Trastuzumab for breast cancer.

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The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in liver transplant candidates, to determine agreement between cardiopulmonary exercise testing and dobutamine stress echocardiogram (SOC) for the identification of cirrhotic cardiomyopathy in liver transplant candidates, and to determine agreement between peak oxygen consumption from cardiopulmonary exercise testing and the liver frailty index or the six-minute walk test (SOC), for the identification of frailty in liver transplant candidates.

The purpose of this study is to determine the change in exercise capacity by comparing VO2 max results pre & post renal transplant.

This randomized phase IIb trial studies how well low-dose carvedilol works in preventing heart failure in cancer survivors exposed to high dose anthracyclines for management of childhood cancer. Patients who received high-dose anthracycline chemotherapy are at a much greater risk for developing heart failure compared to survivors who didn't get any anthracycline chemotherapy. Heart failure happens when the heart muscle has been weakened and can't pump blood as well as it should. Carvedilol may help lower the risk of cardiovascular complications.

The purpose of this study is to determine if Brain Natriuretic Peptide (NT-pro-BNP) values increase over time in breast cancer survivors and correlate with cardiac dysfunction. This study will define the average NT-pro-B-natriuretic peptide values in female breast cancer patients 1, 2, 3, 4, and 5 years out from anthracycline-based chemotherapy.

This pilot study involves very frequent monitoring of breast cancer patient blood levels of hs-cTnT Troponin and n-t-BNP (Brain Natriuretic Peptide) before and after initiation of chemotherapy with either adriamycin or trastuzumab in order to define the kinetics of both biomarkers during the first two cycles of chemotherapy. Cardiac troponins and BNP are frequently elevated after experimental chemotherapy in animal models. Their behavior in humans has been inconsistent, with occasional elevations seen, usually within 30 days of therapy. Assays for troponin with sensitivity into the pg/ml range have now been introduced. A majority of patients greater than age 50 have ...

The purpose of this study is to evaluate the effects of menopause transition on myocardial stiffness in healthy female subjects without a history of heart disease who are expected to be close to the average age of menopause transition (~51 years), in the 48-53 year age range. All eligible subjects will undergo two study visits that will include a cardiac MRI/MRE exam, echocardiography imaging and blood test.

The purpose of this aim is to characterize the relationship between the serum estradiol level and myocardial stiffness changes in young women (<46) on estradiol replacement therapy after bilateral oophorectomy.  Subjects will be ...

The purpose of this study is to determine if exercise improves cardiac remodeling as a way to mitigate the negative effects of chemotherapy and radiation therapy which lead to reduced exercise tolerance.