Clinical Trials

This study will determine what factors are involved in recruiting lung surface area for gas exchange during exercise in HFpEF patients, providing insight into the relationship between lung diffusing capacity and pulmonary vascular pressures.
 

The purpose of this study is to:

1. Define and determine the prevalence of pulmonary vascular disease and diastolic dysfunction as assessed by the gold standard of invasive hemodynamic cardiopulmonary exercise testing.
2. Determine the role of rest-exercise echocardiography for the assessment hemodynamics in Fontan physiology.
3. Evaluate the clinical impact of pulmonary vascular disease and ventricular diastolic dysfunction.

The purpose of this study is to investigate the effect of non-invasive low intensity venous distension on the activation of locomotor muscle group III afferents on ventilation, gas exchange, blood pressure, and cardiac function responses in healthy individuals.

The purpose of this study is to compare cardiopulmonary exercise testing with no filter to pre- and post-flow sensor placement.

The purpose of this study is to determine the effect of continuous positive airway pressure on cardiopulmonary and symptomatic responses to cardiopulmonary exercise testing in patients with Expiratory Central Airway Collapse.

The purpose of this study is to compare the difference in the ability to detect blood flow abnormalities between invasive assessments performed at rest versus exercise.

Right ventricular (RV) pacemaker dependent patients without left ventricular (LV) systolic or diastolic dysfunction at baseline will demonstrate worse LV diastolic and systolic function and pulmonary gas exchange reserve during exercise stress compared to patients with physiologic pacing.

The purpose of this study is to evaluate the ability to determine the first heart sound (S1) and its relationship to aerobic capacity.

This study will determine if the use of multimedia in the form of video running simulation and music to current exercise testing protocols will increase maximal exercise testing in children.

The purpose of this study is to evaluate the effectiveness and safety of aficamten (CK-3773274) in adults with symptomatic hypertrophic cardiomyopathy and left ventricular outflow tract obstruction.

Cardiopulmonary rehabilitation (CP rehab) with an exercise component is important in the care from many people with heart or lung disease. Measuring the benefits of CP rehab (i.e., measuring ‘how well CP rehab works’) depends upon having tests or ‘tools’ that can very well detect positive changes in physical and clinical function. One such tool is maximal cardiopulmonary exercise testing (CPET). This is the gold standard for measuring exercise capacity. However, maximal CPET is expensive, has extensive set-up and space requirements, needs direct medical supervision, and involves interpretive complexity; these factors have limited the widespread use of maximal ...

The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in liver transplant candidates, to determine agreement between cardiopulmonary exercise testing and dobutamine stress echocardiogram (SOC) for the identification of cirrhotic cardiomyopathy in liver transplant candidates, and to determine agreement between peak oxygen consumption from cardiopulmonary exercise testing and the liver frailty index or the six-minute walk test (SOC), for the identification of frailty in liver transplant candidates.

The purpose of this study is to determine the change in exercise capacity by comparing VO2 max results pre & post renal transplant.