Clinical Trials

The purpose of this study is to assess key characteristics of bone quality, specifically material strength and porosity, in patients who have type 2 diabetes. These patients are at an unexplained increased risk for fractures and there is an urgent need to refine clinical assessment for this risk.

The purpose of this study is to collect safety, effectiveness and pharmacokinetics (in a subgroup of subjects) data on the use of NX9 as an oral CT contrast agent.

This study aims to develop a novel ultra-low dose chest CT technology for use in HHT patients and to determine the lowest possible radiation dose that is achievable without sacrificing the diagnostic quality.

The purpose of this study is to establish a registry for the active surveillance of patients with multiple ground glass opacities (GGOs) in the lung identified on imaging.

The purpose of this study is to assess whether our not the percentage of pulmonary related vascular structures (PRVS) determined by the quantitative CT (Q-CT) tool CALIPER is a novel measure that can be used for the early detection of pulmonary vascular remodeling in patients with SSc.  pulmonary related vascular structures

The purpose of this study is to test the use of ultra-low dose CT scans to find lung nodules compared to the standard routine low dose CT scans.

The purpose of this study is to generate an additional series (reconstruction) of the low contrast dose CT exam utilizing an AI model (general adversarial network (GAN)) to simulate high contrast on CT exams.

Adding a limited noncontrast pelvis CT with Agatston calcium scoring to evaluate and quantify calcified Peyronie plaques can increase the number of patients that qualify for collagenase Clostridium histolyticum (CCH) injection therapy compared with the qualitative assessment by penile duplex Doppler ultrasound (PDDU) and clinical exam.

The purpose of this study is to measure differences in distal radial-ulnar joint movement between injured and uninjured wrists using motion picture CT imaging (4DCT), with the hopes of establishing a less invasive diagnostic tool than arthroscopy.  The belief is that the precise location and characteristics of the injury can be determined by measuring joint spacing during wrist rotation.

The purpose of this study is to verify and quantify the difference in artifact from implanted metal on CT images performed using Multidector Computed Tomography (MDCT) (ordered exam) and Cone Bean Computed Tomography (CBCT) (research exam).

The purpose of this study is to assess healthy controls without any history of wrist injury or diseases by using 4DCT scanning during wrist movement to characterize gapping at the scapholunate, radiolunate, and radioscaphoid joints, as well as the scaphotrapeziotrapezoid (STT) joint.  This will test the hypotheses that scapholunate and STT gapping distances and bilateral asymmetry will be greater in the resisted tasks as compared to the unresisted tasks in both male and female subjects, and that gapping in females will be greater than in males.

The purpose for this study is to compare the ability of identifying uric acid crystals between two CT scanning techniques, one that uses a more common single-source CT scanner and one that uses a dual-source CT scanner, which is less commonly available.

The purpose of this study is to determine the lowest radiation dose that allows interpretation of chest CT scan.

Our group developed a novel chest CT technology with reduced radiation exposure and procedure duration. This is a new dose optimization and efficiency technology and a tin filter, which greatly reduce the radiation dose compared to a standard chest CT. The procedure is fast and can be performed without sedation.  We therefore aim to validate this promising technology as an alternative clinical monitoring tool against current standard-of-care with CXR. 

The purpose of this study is to develop a highly sensitive clinical prediction rule to identify patients with neutropenic fever who are at increased risk of having abdominal source of the infection.

The purpose of this study is to see how the contrast affects your kidney function. Your kidney function will be measured by testing several blood and urine samples that you provide before and after the CT scan or arterial interventional procedure. A CT scan of your kidneys will also be performed after the CT scan or arterial interventional procedure.

The investigators will test the impact of a decision aid, Head CT Choice, to determine if its use improves parents' knowledge and engagement in decision making and safely decreases healthcare utilization in children presenting to the emergency department with blunt head trauma.

Aims, purpose, or objectives: Evaluate the use and interest of computed tomography as a new tool in Aortic Stenosis evaluation and risk stratification. The objective is to evaluate the impact of new computed tomography indices (global calcification, localized calcification, anatomic measurements…) in aortic stenosis management.

The purpose of this study is to:

1. To determine if readers with similar levels of training have interchangeable performance for detection of hepatic metastases.
2. “Pseudoreaders” can be created from evaluations of different radiologists to rank different dose/reconstruction alternatives without alteration of results obtained using fully-crossed multi-reader, multi-case study designs

The primary purpose of this study is to evaluate the effectiveness of automatic adaptive iterative metal artifcate reduction (AiMAR) in improving image quality in CT scans of different body parts in patients with different metal implants in terms of artifact reduction and visualization of key anatomic structures.

The primary purpose of this study is to understand the effect of educating patients and encouraging shared decision making on rates of CT scanning in head injured patients by using an already developed app and observing the effect on the health care provider

The purpose of this study is to study accuracy of wearables in measuring body composition after bariatric surgery to detect real-time body composition changes

We hypothesize that clinical studies to investigate the role of individual proteins in kidney stone pathogenesis have likely been confounded by an unknown variety of underlying renal pathologies. Therefore, we propose to examine urinary protein crystallization inhibitors in patient populations that have been carefully phenotyped relative to renal stone precursor lesions by direct endoscopic visualization. In collaboration with Project #1, our second major goal is to use these accurately phenotyped patients in order to adapt modern dual-energy CT technology to develop a reliable noninvasive technique to accurately and noninvasively determine stone composition and visualize the earliest kidney stone precursor lesions. ...

The goal of this study is to develop a clinician-delivered brief narrative (script) for patients undergoing Computed Tomography (CT) scanning of the head, chest or abdomen that introduces clinician attention to patient affect.

The main purpose of this study is to  evaluate new types of gamma camera (the Veriton and Starguide systems) that provide a significant gain in system sensitivity and improved image quality compared to a conventional gamma camera that can achieve equal or better image quality than a standard SPECT/CT system.

The purpose of this study is to

1. Simulate reduced-dose DynaCT images by appropriately adding noise to patient DynaCT images acquired as clinical standard of care and using a standard dose.
2. Assess the clinical utility of the simulated reduced-dose DynaCT images.

The purpose of this study is to evaluate the effectiveness and safety of 30 mg/kg intravenous (IV) infusions of pamrevlumab administered every 3 weeks as compared to placebo in subjects with Idiopathic Pulmonary Fibrosis.

The purpose of this study is to see how the contrast affects kidney function. Kidney function will be measured by testing several blood and urine samples that you provide before and after the CT scan.

The purpose of this study is to determine the tradeoffs between CT image quality and patient radiation dose in a way that moves beyond current simple models (e.g. standard deviation and CTDIvol) by investigating the relationships between task-based metrics of image quality, observer performance, patient size, and patient dose.

The purpose of this study is to determine if models predicting symptomatic recurrence (Recurrence of Kidney Stones score) in  the prospective cohort study (IRB #08-006541) also predict radiographic stone formation and growth among 300 incident stone formers at Mayo Clinic Rochester and 55 incident stone formers at Mayo Clinic Florida in our current prospective cohort. 

The primary focus of this minimal risk study will be to assess and refine the ability of DE CT to accurately determine kidney stone composition.

This study will focus on demonstrating the benefits of Photon Counting Detector CT Scan (PCD-CT) for clinical indications and findings are expected to benefit the diagnosis and characterization of Coronary Artery Disease (CAD) and myocardial perfusion defects.

Specific Aim:  

In patients, measure the clinical impact of cardiac PCD-CT on patient diagnosis and management

The purposes for this study are to determine the ability of volumetric dynamic 4D CTA compared to replace current single-phase CTA and eliminate venous contamination that can decrease scan accuracy. Additionally, we seek to estimate the ability of this new imaging technique (volumetric dynamic 4D CTA) to reduce the dose of intravenous iodine and radiation dose. 

Assessing disease activity in people with Takayasu's arteritis is difficult, as most people with the disease do not exhibit visible, measurable symptoms. Combination positron emission tomography/computed axial tomography (PET/CT) is a particularly sensitive, accurate scanning method that may improve researchers' ability to evaluate people with the disease. This study will determine the effectiveness of PET/CT in assessing disease activity in people with Takayasu's arteritis.

The purpose of this study is to:

1. Prospectively characterize the dynamic systemic hemodynamic changes that occur during dynamic CT myelography.

2. Prospectively characterize the changes in regional cerebral oxygen saturation during dynamic CT myelography and how this technology can be used to guide systemic blood pressure management to enhance cerebral oxygen delivery in the setting of iatrogenically increased ICP.

The purposes of this study are to assess the accuracy of dual-energy CT (DECT) virtual non-calcium technique to detect subtle or occult pelvic or hip fractures in emergency room patients and to assess the impact on confidence of detection of pelvic or hip fractures utilizing the VNCa technique in radiology trainees with varying degrees of training.

The purpose of this study is to determine if a single ZTE MR sequence can replace the need for a CT of the pelvis to avoid an additional exam and avoid the radiation to these patients from CT.

The purpose of this study is to compare the operative outcomes and complications of mini-percutaneous nephrolithotomy (mini-PCNL) versus standard PCNL for renal stones.

The purpose of this study is to investigate radiotracer 18F-tetrafluoroborate (18F-TFB) for imaging of patients with differentiated thyroid cancer

The purpose of this study is to demonstrate the use of 3D ZTE imaging of the cervical spine to assess osseous neural foraminal stenosis and directly compare it to CT. Other objectives will include evaluation of ossification of the posterior longitudinal ligament, ossification of disc herniations, and comparison of ZTE derived imaging of pedicle morphology to the current reformats provided by CT. The ability to image metallic hardware with ZTE will also be assessed, if present; 56 participants.  Other cohorts being added is for those who are returning for aneursym ablation follow-up with medically indicated head MRI (adding reserach ZTE sequence) ...

The purpose of this study is to examine the capability of contrast-enhanced pelvic PCD-CT for local staging of rectal cancer, with dedicated rectal cancer staging MR serving as the reference standard and to determine the optimal high-resolution images (image type [T3D, low keV, iodine map, IR or denoising method] that should be reconstructed after PCD-CT image acquisition for rectal cancer detection and staging.

The Researchers are trying to determine if 68Ga-DOTATATE PET/CT imaging will have a similar accuracy as 18FDG PET/CT in diagnosing cardiac sarcoidosis and if it will be able to do so without the need for complex patient dietary preparation that is required with 18FDG PET/CT.

To establish whether ZTE imaging of the infant calvarium can provide equivalent information to CT, specifically in reference to diagnosis for craniosynostosis.

The purpose of this study is to examine the ability of PCD-CT to (1) display subtle fractures of the wrist using the system’s increased spatial resolution compared to conventional wrist CT and MR; and (2)  evaluate the ability of PCD-CT with virtual non-calcium images to identify bone marrow edema at acute fracture sites.

The purpose of this study is to compare the accuracy of the Auto Registration capability on the EPIQ/PercuNav system against existing manual registration techniques using common anatomical landmarks, for image fusion.

The purpose of this study is to estimate the performance (sensitivity, specificity, accuracy) of dual energy CT for the detection of implant rupture and extracapsular silicone compared to standard multiplanar T1-, T2-weighted and silicone specific MR imaging.

A Study of the ability for CT imaging to accurately predict the fragility (quality of being easily broken) of kidney stones during surgical intervention. 

The purpose of this study is to compare the ability to identify uric acid renal stones between alternate CT scanning techniques and the current dual-source CT scanning technique.

The purpose of this study is to measure the performance of Dual-Energy CT scans that are able to reduce interference caused by metal objects, and then compare with standard echocardiography for checking patients with LVAD devices.

This phase II trial studies fluorothymidine F 18 (FLT) positron emission tomography (PET)/computed tomography (CT) in measuring response in patients with previously untreated acute myeloid leukemia. FLT is a radioactive substance that may "light up" where cancer is in the body. FLT is injected into the blood and builds up in cells that are dividing, including cancer cells. Diagnostic procedures, such as PET/CT, may help measure a patient's response to earlier treatment.

To determine the tumor radiotracer uptake of direct hepatic intraarterial (I.A.) versus systemic intravenous (I.V.) 68Ga-PSMA in patients with PSMA+ HCC by PET/CT. 

For most brain tumors, radiation treatment is guided by a Magnetic Resonance Imaging (MRI) scan. In this study, information from a special scan, called a Positron Emission Tomography/ Computed Tomography (PET/CT) scan using an amino acid called Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) will also be used to image the tumor and guide your radiation oncologist in determining locations to treat with radiation. This type of scan has shown promise in being able to better distinguish tumor from normal brain tissue and may help to more accurately plan radiation treatment. This type of scan can also assist the radiation oncologist in identifying the most ...

The purpose of this study is to determine the performance of Dual-Energy CT (DECT) with Virtual Non-calcium (VNCa) and fat measurement in assessing multiple myeloma disease activity following treatment, with MRI and clinical/ laboratory parameters as reference standards.

The first objective of this pilot research protocol is to evaluate the quality of PET from the SIGNA PET/MR system and to compare the quantitative accuracy of PET images from the PET/MR system to PET images from a standard PET/CT system. The second objective of this pilot research protocol is to compare the image quality from MRI images acquired on the SIGNA PET/MR to clinical MR images acquired on a standard 3.0T MRI system.

The purpose of this study is to compare the accuracy of wearables in measuring body composition with artificial intelligence (AI) body composition of CT scan or body composition machine.

Monitoring body composition can provide valuable information regarding nutritional status in many conditions and can be an early indicator of disease. Traditionally, body composition is measured by DEXA scan or other cross-sectional images manually. Recently, an AI algorithm has been developed to measure body composition in Computed tomography (CT) scan. Body composition can also be measured using bioelectrical impedance, the technology behind the Samsung galaxy watch 4 and ...

This study evaluates the diagnostic performance and safety of [18F]PSMA-1007 PET/CT imaging in patients with suspected recurrence of prostate cancer after previous definitive treatment.

Investigators are doing this study to determine which of four imaging techniques: Fludeoxyglucose Positron Emission Tomography (18 FDG PET) computerized tomography (CT), 18 FDG PET Magnetic resonance imaging (MRI), C-11 acetate PET CT, and C-11 acetate PET MRI) is the best test for finding sites of active myeloma disease.

The purpose of this study is to evaluate the effectiveness of vertebral fracture assessment (VFA) in evaluation of asymptomatic fracture in pre-liver transplant patients as compared to the current standard of care using spine x-ray
 

Our purpose for this study is to help design a therapy plan that can decrease extra radiation exposure to your heart during radiotherapy. The therapy plan will use images obtained using a dual-source CT scanner

The purpose of this study is to examine the utility of 68GaFAPI-46 PET/CT imaging in adult patients with biopsy-proven Pancreatic Ductal Adenocarcinoma (PDA) who have no prior treatment for their PDA and who are expected to undergo surgical resection following NAT. 

The purpose of this study is to evaluate the ability of [68Ga]FAPI-46 to detect FAP expressing cells in patients with resectable or borderline resectable PDAC. The [68Ga]FAPI-46 PET scans will be acquired after initial staging using institutional standard methods. If the participant is prescribed neoadjuvant therapy, a second [68Ga]FAPI-46 PET scan will be performed within 21 days prior to planned surgical resection. 

The primary objective of the study is to evaluate the sensitivity and specificity of a blood-based GuardantLUNAR-2 test to detect high frequency cancer in screen-relevant populations.

The purpose of this story is to identify key radiographic variables that are predictive of symptomatic improvement in those patients undergoing endobronchial valve placement.  

Symptomatic management of emphysema continues to be a difficult task by medical therapy alone. Bronchoscopic lung volume reduction (BLVR), utilizing minimal invasive placement of endobronchial valves, has emerged as a new therapeutic option. Early trial data demonstrated statistically and clinically significant improvement in FEV1, 6 minutes walk (6MW) distance, and quality of life.  However, following the procedure, there are currently no good early predictors of symptomatic benefit. Often, patients wait several months to ...

The purpose of this study is to estimate the performance (sensitivity, specificity, accuracy) of dual-energy CT of the breast for detection of breast cancer in the ipsilateral and contralateral breast compared to standard multihance breast MR imaging.  To determine the optimal workflow and images needed (multiplanar reconstructions, color maps, etc.) needed for routine interpretation of DE or quantitative CT imaging of contrast enhanced breast DECT.

The purpose of this study is to assess the current rate of adherence to incidental lung nodule management and lung cancer screening guidelines in at-risk lung cancer patients identified from chart review.

The purpose of this study is to evaluate the feasibility and diagnostic performance of 68Ga PSMA-dual contrast PET/MRI for detection and staging of Hepatocellular Carcinoma (HCC), and to compare it with standard-of-care (SOC) imaging. Additionally, this study aims to identify the biologic correlates of biomarkers derived from 68Ga PSMA-dual contrast PET/MRI with histopathology features and PSMA immunostaining of HCC.

Biomarkers from circulating cell-free tumor DNA in peripheral blood will identify patients with metastatic prostate cancer diagnosed with C11 choline PET/CT who will benefit from metastasis-directed radiation, ablative therapies, and/or surgery. Tissue and blood will be collected before treatment. If patients receive androgen deprivation, then blood will be collected after neoadjuvant androgen deprivation but before radiation, ablative therapies, or surgery. Subsequent samples will be obtained at 3 months and 6 months following treatment, after which no further patient contact will occur.

The purpose of this study is to assess the combined impact of post-processing methods that quantify potential biomarkers of chronic liver disease (AEF, fECS) and that improve iodine signal (vMono+) on detecting liver fibrosis and hepatic masses or esophageal varices, in comparison to routine contrast-enhanced liver CT.

The purpose of this study is to examine PSMA and C-11 Choline PET in patients with suspected metastatic prostate cancer who have been imaged with 11C-Choline PET clinically and with PSMA PET (either Gallium-68 labeled HBED-CC PSMA (more commonly called 68Ga-PSMA-11) or F-18 PSMA 1007) in order to demonstrate their utility in detecting prostate cancer.

The purpose of this study is to investigate post-operative changes in cardiac structure and function for patients with mitral regurgitation to define heart remodeling.

The purpose of this study is the diagnostic 68Ga-PSMA-11 PET/CT imaging for screening prior to consideration of 177Lu-PSMA-617 therapy.

The general aim of this proposal is to evaluate new non-significant risk (NSR) MRI technology in a clinical setting, specifically the use of preclinical (non-FDA-approved) sequences (including but not limited to bSSFP, SSFSE) which have been modified from their standard counterparts to include interleaved 1D body navigator pulses.

The purpose of this study is to evaluate if clazosentan (on top of normal routine medical care) can reduce the risk of developing complications related to cerebral vasospasm and permanent brain damage as compared to normal routine medical care alone.

The purpose of this study is to test how well an imaging procedure called fludeoxyglucose F-18 (FDG) positron emission tomography/computed tomography (PET/CT) works in predicting response to standard of care chemotherapy prior to surgery in patients with HER2-positive stage IIa-IIIc breast cancer. FDG is a radioactive tracer that is given in a vein before PET/CT imaging and helps to identify areas of active cancer.  

The purpose o fthis study

A total of 8,000 patients presenting to CPSs with acute-onset AIS, ICH or aSAH and no history of dementia will be enrolled within 6 weeks of stroke onset.

All participants will undergo baseline screening for evidence of pre-stroke dementia. Those who pass baseline screening will complete a blood draw and a series of cognitive and functional assessments at baseline.

Participants will undergo in-person (3-6 months, 18 months) and telephone (annual) follow-up visits for the duration of the study to assess for longitudinal cognitive and functional outcomes. In addition to Tier 1 procedures, at each in-person follow-up visit: Tier ...

This phase II trial studies F-18 16 alpha-fluoroestradiol (FES) positron emission tomography (PET)/computed tomography (CT) in predicting response to endocrine therapy in patients with newly diagnosed breast cancer that has spread to other parts of the body. FES is a radioactive form of the hormone estrogen and may "light up" where cancer is in the body. Diagnostic procedures using FES, such as FES PET/CT, may help measure the FES and help doctors predict how well the cancer will respond to treatment.

The purpose of this study is to detect whether arm rotation (pronation vs. supination) affects glenohumeral alignment. If so, does this impact what prosthesis would be used for a shoulder arthroplasty?

The purpose of this study is to evaluate whether a reduction in the dose of consolidation radiation therapy (RT) in patients who achieve a negative post-chemotherapy PET-CT scan following 3 to 6 cycles of chemoimmunotherapy, will be associated with a low risk of in-field failure.

The Patient Group 1 primary objective is to measure the distribution of 90Y glass microspheres throughout the tumor and non-tumor hepatic parenchyma, as assessed by same day postradioembolization study-specific non-FDG PET/CT scan. Correlate this measurement with mean lobar absorbed radiation dose and embolic load given to patients and time taken to achieve adequate Future Liver Remnant (> 40% of total liver volume) to determine if there is an optimal lobar dose and embolic load.

The Patient Group 2 primary objectives are to assess the association of circulating and imaging biomarkers on Future Liver Remnant hypertrophy, and to assess progression-free survival between ...

The purpose of this study is to analyze the effect of parity, menopause and reproductive lifespan on kidney structure and function.