Arthur J. Sit, M.D., M.S.

The purpose of this study is to use Ultrasound surface wave elastography to measure and compare the tissue thickness and elasticity in normal eyes and eyes with glaucoma. The goal is to understand the association between tissue characteristics and glaucoma.

The purpose of this study is to identify reasons for variations in eye pressure response to glaucoma drugs between individuals. 

The purpose of this study is to determine the action of NCX 470 ophthalmic solution, 0.1% on aqueous humor dynamic parameters in healthy volunteers or subjects with ocular hypertension (OHT).

The purpose of this study to optimize SLT application when used in the management of open angle glaucoma (OAG).  

The purpose of this study is to evaluate outflow facility and ocular biomechanical properties in vitrectomized eyes compared to fellow non-vitrectomized eyes.

To evaluate the effect of netarsudil (AR-13324) ophthalmic solution on aqueous humor dynamics relative to its placebo.

To evaluate the effect on trabecular outflow facility of Netarsudil ophthalmic solution 0.02% compared to placebo

The purpose of this study is to find out how much the eye pressure increases after giving the injection, and what happens to the blood supply of the various parts of the eye.

Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large IOP fluctuation. Our purpose of this research project is to address this critical barrier by focusing on physiological factors that predict IOP response to drugs.

The purpose of this study is to understand the aqueous humor dynamics changes that occur with glaucoma therapies and provocative tests. 

To determine the reasons why eye pressure varies over time and between individuals. For patients with glaucoma, we are also trying to determine the mechanisms that control changes in eye pressure with the disease and standard treatments.

The purpose of this study is to determine the changes in in-vivo aqueous outflow facility following scleral buckling, allowing for a more accurate understanding of how the eye adapts to the presence of the encircling band.

The purpose of this study is to assess for changes in the structure and function of the optic nerve caused by changes in cerebrospinal fluid pressure.

The purpose of this study is to gather information for comparing eye venous pressure measurement in different body positions and 2 measuring devices.

The primary purpose of this study is to determine the effect of latanoprostene bunod (LBN) ophthalmic solution 0.024% (a single dose and 7 days of once daily [QD] dosing) on 2 aspects of aqueous humor (AqH) dynamics (episcleral venous pressure [EVP] and outflow facility) in participants with ocular hypertension (OHT).

Phenylephrine hydrochloride ophthalmic solution is an alpha-1 adrenergic receptor agonist commonly used topically for dilation prior to ocular fundus examination. In the eye, phenylephrine acts locally as a potent vasoconstrictor and mydriatic by constricting ophthalmic blood vessels and the radial dilator muscle of the iris. Episcleral venous pressure (EVP) is a determinant of intraocular pressure (IOP) and can be measured non-invasively by venomanometry. Since phenylephrine is a vasoconstrictor, it may affect episcleral venous tone, but the effect on EVP is unknown. Understanding the physiology of episcleral veins helps us in better understanding of pathophysiology of glaucoma.

We are doing this research study to find out the genetic and environmental factors that contribute to glaucoma (high pressure in the eye), which can cause vision loss and blindness if untreated. Exfoliation syndrome is a common condition that can lead to exfoliation glaucoma. The most common form of glaucoma is called primary open angle glaucoma. Identifying the factors that lead to exfoliation syndrome and glaucoma may help us to develop future tests and treatments for these conditions.

The purpose of this study is to analyze the postural variations in mean ocular perfusion pressure in Glaucoma patients and compare with a healthy age matched control group.

The purpose of this study is to investigate the daily variations in episcleral venous pressure (EVP), the relationship between EVP and blood pressure (BP) variations, and the effect of anti-hypertension medications on these variations. The effect of blood volume increase after water drinking on BP, intraocular pressure (IOP), and EVP will also be assessed.