Clinical Trials

The purpose of this study is to describe the clinical impact of cardiac rehabilitation in patients who have undergone myectomy for hypertrophic cardiomyopathy.  Compare the clinical outcomes of patients who have attended cardiac rehab with those who have not attended after myectomy for hypertrophic cardiomyopathy. 

Dementia is a disease that causes a person to lose their memory, speech, and thinking skills. People with heart disease are at high risk of brain function decline, that can lead to dementia. Reduced blood flow to the brain can cause this decline in brain function. Factors linked with heart disease (such as poor blood vessel function and low fitness level) also lead to reduced brain blood flow. Exercise training can improve these factors. However, it is unknown what type of training is best for improving brain blood flow and function.

High intensity interval training (HIIT) is ...

The purpose of this study is to measure overall activity (sedentary-to-high intensity) during rehab and at 1 year follow-up.  

We are currently enrolling both healthy volunteers and people who have been diagnosed with heart failure to participate in our research study.  The purpose of this study is to better understand the relationship between exercise, breathing, blood flow and blood pressure.  This study includes two study visits if you are a healthy or heart failure volunteer.    All testing will be performed at our testing center at St. Mary’s Hospital located in Rochester, MN. 

On the first study visit, the research activities will be discussed and all questions will be answered. Once written consent is provided and the ...

The purpose of this study is to evaluate comparisons between a hybrid program of center-based CR which incorporates mHealth remote case management technology (CON+) to a traditional center-based program alone (CON) as well as comparisons between home-based mHealth remote case management alone (HOM+) to a traditional center-based program (CON).

The purpose of this study is to assess the frequency, and the various patient, program, and system characteristics for patients who do not complete cardiac rehabilitation versus those who do. The study would like to identify potential ways to improve cardiac rehabilitation completion.

The purpose of this study is to assess frailty in patients being evaluated in the Congestive Heart Failure Clinic with NYHA class III-IV heart failure and to enroll these patients in cardiac rehabilitation program aimed at improving frailty and functional independence.

The purpose of this study will be to evaluate our current practice of prescribing High-intensity aerobic interval training (HIIT0. Specifically, we will document the progression of patients performing HIIT and measure the physiologic and perceptual responses (heart rate, blood pressure, directly measured VO2, RPE, patient acceptance of HIIT) during HIIT sessions in a cohort of patients throughout their three month cardiac rehabilitation (CR) program following our standard HIIT protocol.

Participants with heart failure with preserved ejection fraction will undergo 12 weeks of cardiac rehabilitation for exercise training (ET) and be randomized to either nebulized sodium nitrite inhalation solution or placebo inhalation solution (normal saline) through the training period. Study drug is administered 3 times daily during daytime hours with one of these doses being immediately prior to onset of ET sessions throughout the 12 week trial. The objective is to determine if the inhaled sodium nitrite improves the clinical responses and tolerability of ET.

The overarching aim of this project will be to objectively characterizing the frailty phenotype and to assess the prevalence and sex differences of frailty in outpatient cardiac rehabilitation participants. The current proposal seeks to facilitate identification of vulnerable women and adapt their referral, assessment, intervention plan and goals to individualize exercise prescription and improve overall frailty.

The purpose of this study is to assess barriers to completion of cardiac rehabilitation program and to identify potential ways to improve cardiac rehabilitation completion.

The purpose of this study is to examine PRO-HIIT compared with CON-HIIT on effectiveness for improving locomotor muscle mitochondrial function in heart failure (HF) patients.

This study is a pilot study evaluating the feasibility and early efficacy of cardiac rehabilitation to improve frailty and symptoms in patients with advanced heart failure (NYHA class III-IV), who are being considered for LVAD therapy.

The purpose of this study is to compare resting blood pressure, heart rate, and quality of life outcomes in cardiac rehab patients with canine involvement versus traditional cardiac rehab therapy alone.

The purpose of this study is to evaluate the impact of interventions on important CV biomarkers to provide valuable information on the mechanism linking depression and anxiety to cardiac prognosis resulting in improved quality of life and diagnosis.

The purpose of this research is to to determine whether home-based cardiac rehabilitation (CR) is an effective intervention to improve decreased physical function in patients with varying levels of kidney function. We will determine if home-based CR improves frailty parameters and SPPB scores. We will also determine if home-based CR improves health-related quality of life (HRQOL), body composition, physical activity, and adverse outcomes, including hospitalizations and death.

Cardiopulmonary rehabilitation (CP rehab) with an exercise component is important in the care from many people with heart or lung disease. Measuring the benefits of CP rehab (i.e., measuring ‘how well CP rehab works’) depends upon having tests or ‘tools’ that can very well detect positive changes in physical and clinical function. One such tool is maximal cardiopulmonary exercise testing (CPET). This is the gold standard for measuring exercise capacity. However, maximal CPET is expensive, has extensive set-up and space requirements, needs direct medical supervision, and involves interpretive complexity; these factors have limited the widespread use of maximal ...

A multicenter prospective randomized clinical trial testing the hypothesis that a patient-centered actigraphy intervention will result in increased physical activity for frail older adults increase during the critical first 30 days after a cardiovascular hospitalization.

The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. 

The objectives of this study are to examine the prevalence of comorbid sleep disordered breathing (SDB) and insomnia in post-MI patients enrolled in cardiac rehabilitation (CR), to assess whether post-MI CR patients with comorbid SDB and insomnia exhibit a more unfavorable CV profile than those without, and to determine whether post-MI CR patients with comorbid SDB and insomnia show less adherence to CR than those without.

The aim of this project is to assess the feasibility and utility of a virtual world-based cardiac rehabilitation (CR) program as an extension of a face-to-face conventional CR program (Destination Rehab).