Clinical Trials

The purpose of this study is to evaluate the possibility of using echocardiography to measure heart muscle elasticity in clinical practice.

The primary purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between echocardiographic assessments performed at rest versus exercise. 

In this study, we attempt to evaluate the LV and RV myocardial mechanical properties   in patients with myocarditis during the acute and convalescent phases.

The purpose of this study is detection of relationship between biomarkers and the severity of AS (echocardiographic hemodynamics/CT-calcium load).  Detection of relationship between biomarkers to the consequences of AS on the LV (echo remodeling parameters and speckle-tracking LV strain).  Detection of differences on echocardiographic and CT-calcium load AS severity assessments between tricuspid and bicuspid valves.  Detection of biomarker associations with AS hemodynamics, CT-calcium load, LV remodeling and LV strain between tricuspid and bicuspid phenotypes. 

The study aims to answer whether the use of a mixture of blood and saline alone (limited air) provides the same degree of right-heart contrast enhancement as compared to the standard agitated saline (with air), during  echocardiograms.

The purpose of this study is to compare the value and practicality of using 3D color doppler echocardiography of the vena contracta area versus the standard 2D method when needing accurate measurement of mitral valve regurgitation.

The purpose of this study is to see if using two-dimensional speckle tracking echocardiography improves the initial diagnosis of acute coronary syndrome in patients with chest pain who visit the emergency department. 

The purpose of this study is to determine if 3D volumetric measurements will allow more robust quantification of valvular heart disease severity.

This study is being done to find out if and how much the use of RTMPE improves a provider's confidence in the diagnosis they assign. This is important because the use of RTMPE may decrease the need for any additional invasive testing.

The purpose of this study is to validate novel echocardiographic parameters and algorithms to quantitatively evaluate right ventricular function in patients with Hypoplastic Left Heart Syndrome (HLHS) by applying these methods to previously acquired echocardiographic examinations. 

The purpose of this study is to evaluate the use of Hand-Held Echocardiography (HHE) as a diagnostic tool and extension of physical assessment by trained Advanced Practice Providers (APPs) in patients admitted with congestive heart failure (CHF) in comparison to that of an expert

The purpose of this study is to determine if the change in pulmonary vascular compliance with positional changes (upright, supine, and Trendelenburg position) is different in younger versus older individuals.

The purpose of this study is to establish safety and preliminary effectiveness of treatment with MYK-491 in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants .

The early detection of Bevacizumab or Sunitinib caused cardiotoxicity using cardiac biomarkers and new Transthoracic Echocardiogram (TTE) techniques may allow the adjustment of treatment and/or the administration of prophylactic heart protective agents, prior to the development of irreversible cardiac dysfunction. We hypothesize that cardiac biomarkers, TVI/strain-derived indices will be able to accurately detect subtle cardiac injury at a time when conventional Left Ventricular Ejection Fraction (LVEF) remains normal.  Additionally, we hypothesize that Endothelial Function Test (EndoPAT) testing can detect early endothelial dysfunction.

The purpose of this study is to see if the use of real time ultrasound of heart muscle perfusion is a usable and effective non-invasive way to detect Coronary Allograft Vasculopathy (heart transplant caused blood vessel disease) in child and adult heart transplant patients.

The purpose of this study is to measure the characteristics of the walls of an enlarged aortic blood vessel using non-invasive heart echo to help predict how quickly the enlargement may develop.

The purpose of this study is to provide the incremental clinically useful information of three-dimensional transesophageal echocardiography (3D TEE) over two-dimensional transesophageal echocardiography (2D TEE) as a guide to transseptal puncture.

The purpose of this study is to assess the feasibility of color M mode and standard vena contracta measurements and compare these to novel measurements of aortic regurgitation in left ventricular assist devices (LVADs).

The purpose of this study is to demonstrate the performance and safety of intracardiac echocardiography (ICE) system to guide cardiac interventional percutaneous procedures when used according to its instructions for use (IFU) in standard clinical practice.

The purpose of this study is to assess echo findings of pectus patients in the supine and sitting positions and correlate to symptoms and limitations.

The purpose of this study is to determine the feasibility of ultrasound microvessel imaging to image patient kidneys in vivo.
 

The purpose of this study is for evaluating an ultrasound-based technology (similar to standard clinical echocardiography) for measuring the stiffness of your heart muscle and your peripheral arteries. This type of information may prove to be clinically important.

The overall goal of this study is to investigate the improvement of sensitivity and penetration of a new contrast enhanced ultrasound (CEUS) technology over those of traditional CEUS.

This study (SE2030) will establish a platform of data to build the perfect stress echo test, suitable for all patients, anywhere, anytime, also quantitative and operator independent.

The purpose of this study is to evaluate the transthoracic echocardiographic (TTE) findings associated with rapid weight loss and season training among competitive collegiate wrestlers. In addition,to evaluate body composition, weight loss methods and energy availability at different time points during the season.

We hypothesize that the degree of rapid weight loss will be associated with abnormalities of myocardial function.

The purpose of this study is to evaluate the degree of change to cardiac strain using speckle tracking echocardiography.

The purpose of this study is to determine if two-dimensional speckle tracking echocardiography (2D-STE) derived-strain can detect early myocardial dysfunction and thus predict cardiotoxicity in sarcoma subjects undergoing anthracycline therapy and to compare three dimensional speckle tracking echocardiography (3D-STE) to 2D-STE in the same group of patients.

The purpose of the study is to test whether cardio-ankle vascular index, a measure of arterial stiffness that can be obtained in the office setting, is associated with cardiac function and structure as assessed by echocardiography.

This study is being done to evaluate correlations between echocardiographic Doppler parameters and invasively-measured hemodynamics both at rest and during exercise in a broad cohort of patients referred for cardiac catheterization.

The objectives of this study are: (1) to analyze beat-to-beat variability and the variations of R-R interval to pre-preceding R-R interval (RRp/RRpp) ratio of left ventricular (LV) function by strain imaging (2D speckle tracking echocardiography) in patients with atrial fibrillation (AF) undergoing electrical cardioversion(ECV) or radiofrequency catheter ablation (RFCA) as a predictor of a recovery of LV function and volume after restoration of sinus rhythm , (2) to evaluate left atrial mechanics as a predictor of for AF recurrence after electrical cardioversion (ECV) or radiofrequency catheter ablation (RFCA)

The purpose of this study is to evaluate the standard Myocardial Blood Volume Measurement (MBV) by Real-Time Myocardial Perfusion Echocardiography (RTMPE) and compare this to the myocardial volume ratio by Cardiac Magnetic Resonance (CMR).

The purpose of this study is to utilize three dimensional (3D) transesophageal echocardiography (TEE) or 3D transthoracic echocardiography (TTE) to measure various mitral chordal, annular, and leaflet measurements and LV size to better understand the mechanism of regurgitation in patients with FMR.

The aim of this study is to prospectively validate the novel AI based model in patients undergoing clinically indicated transthoracic echocardiography using a four-chamber view acquired with a hand-held point of care ultrasound.

The purpose of this study is to compare conventional assessment of systolic ventricular function on a 2D heart echo with an assessment of more immediate changes in heart mechanics using 2D and 3D measurements of deformation and strain in patients undergoing infusion of Trastuzumab for breast cancer.

The purpose of this study is to verify that high Premature Ventricular Complex (PVC) burden is associated with increased risk of stroke and/or Transient Ischemic Attack (TIA), to examine outcomes such as stroke/TIA, atrial fibrillation/flutter, and all-cause mortality associated with PVCs, and to evaluate whether PVCs are associated with development of appendage dysfunction.

The purpose of this study is to identify patients presenting to the echocardiogram laboratroy for routine clinically indicated echocardiography or to the cardiac catheterization laboratory for routine clinically indicated catheterization procedures. These patients will undergo a cardiac physical examination using the ( VoqX) stethoscope for the following 2 aims:

1) Collect computerized auscultation data to train the ©VoqX device on how a variety of cardiac pathologies "sound", including normal heart sounds, aortic stenosis, and mitral valve disease, after identifying these cardiac pathologies using gold-standard testing with echocardiography or invasive cardiac catheterization.

2)Prospectively determine the accuracy of the ©VoqX device as a tool to non-invasively screen for ...

The purpose of this study is to evaluate the use of a non-invasive bedside echocardiography to assess the effect of mechanical ventilation (invasive and non-invasive) on the function of the heart.

The purpose of this study is to evaluate Patent Foramen Ovale (PFO) closure for migraine headache relief using the GORE® CARDIOFORM Septal Occluder after a trial of oral anticoagulation therapy vs. placebo for a 6 week period.

The purpose of this study is to determine if it is possible to record a high quality fetal ECG using signals acquired inside of the birth canal (vagina). 

The purpose of this study is to improve the noninvasive assessment of right atrial pressures by correlating tradiational echo findings with other echo indicators using the gold standard of right heart catheterization as the correlation.

The purpose of this study is to assess the correlation between myocardial elasticity (ME) measurements obtained simultaneously during cardiac hemodynamic catheterization and intraprocedural echocardiography.

The purpose of this study is to perform and analyze standard transthoracic echocardiography with contrast and strain imaging in 80 consecutive patients seen in the Mayo Clinic Spontaneous Coronary Artery Dissection (SCAD) Clinic and interpret any prior pre- or post-SCAD echocardiogram studies for comparison.

The purpose of this study is to compare echocardiographic between acute and chronic severe AR patients at baseline and after surgical aortic valve replacement.

The purpose of this study is to determine whether patients diagnosed with severe aortic stenosis have a measurable change in heart function as measured by a new technique (3D echocardiographic strain) compared to controls and to determine whether they show a significant improvement in heart function (as measured by 3D strain) during intermediate-term follow up after aortic valve replacement.

We hypothesize that (1) Patients with significant left atrial pressure (LAP) reduction during transcatheter mitral valve repair (TMVR) have lower cardiac output, more advanced diastolic dysfunction, increased left atrial stiffness, abnormal pulmonary vascular function and higher arterial afterload compared to TMVR patients without a significant LAP reduction. (2) TMVR and associated reduction in mitral regurgitation and LAP results in relief of pulmonary vascular congestion, and improvement in pulmonary vascular and right ventricular function.

The study aims to analyze echocardiogram data of women of reproductive age (18-45) with known bicuspid aortic valve disease and determine if pregnancy leads to increased rates of aortic dilation, surgical repair and/or dissection.

Classical echocardiographic assessment of heart valves is critical in determination of disease severity. However, echocardiography has only limited ability to predict how well an individual patient will do at time of surgery. New echocardiographic technology allows us to measure new, more refined parameters of your heart’s performance. This study is investigating whether these new parameters are better in predicting outcomes.