Clinical Trials

The purpose of this study is to identify how an interactive medical record timeline may improve the chart-review process for clinicians evaluating unfamiliar patients with complex medical/surgical histories in the ICU.

The purpose of this study is to evaluate the subjective impressions on workload demands compared to perceived benefits of a new quality improvement plan of patient care in the Pediatric Intensive Care Unit. The frequency and length of education and training sessions will also be recorded, and PICU patient charts (electronic health records) will be reviewed to document the number and frequency of consults and adherence to the patient care plan.

The purpose of this study is to assess the effectiveness of an Ethics Early Action Protocol and online, team-based ethics orientation in promoting ethics self-efficacy, reducing moral stress/distress, and creating a collaborative approach to managing ethically difficult situations.

The purpose of this study is to evaluate the safety and feasibility of kefir administration in critically ill adults.

The purpose of this study is to develop an interactive medical record timeline based on physician preferences and perceived clinical needs, to improve the chart review process for new patient encounters in the ICU.

The purpose of this study is to develop a passive digital marker (PDM) for delirium severity and examine its performance in comparison to validated delirium severity tools (CAM-ICU-7, ICDSC).

The purpose of this study is to evaluate the immunobiology of influenza virus-related critical illness in young hosts.

Pediatric Intensive Care Influenza Study #2 (PICFLU2) is a multiyear, multicenter prospective observational study in patients aged ≤ 21 years hospitalized in pediatric Intensive Care Units (PICUs) and Stepdown (or intermediate) Care Units (SDUs) in the US. designed 

The purpose of this study is to enable the recognition ability of a camera by providing its training in advance to detect breathing tubes and oxygen masks on any person’s face and reliably recognize signature features of acute brain failure displayed by the patient.

The specific aim for this study is to develop a Computer Vision model using a camera to automatically detect the presence of an endotracheal tube (ETT), an oxygen mask, or a noninvasive ventilation device on patients in the ICU.Digital Video Recordings (DVRs) have played an important role in patient care as preventive and remote monitoring. ...

The SOFA score is a severity of illness and prognostic score used in the ICU. It has also recently been adopted as part of the definition of sepsis. This study will evaluate the usability of automated SOFA scoring for ICU patients within an electronic patient monitoring dashboard. It will also assess for changes in physician ordering (volume and types of orders) after automatic scoring is implemented.

The purpose of this study is to determine the average volume of blood drawn in a 24 hour period in a hemodynamically stable, euvolemic Trauma/Surgical ICU patient and compare the actual volumes of blood loss with routine phlebotomy to expected losses. 

The purpose of this study is to identify important physiologic trends in bedside ICU data such as cerebral perfusion pressure (CPP), intracranial pressure (ICP) using a bedside “Multimodal monitoring” (MMM) computer which utilizes ICM+ Cambridge software.

The purpose of this study is to describe the characteristics and shifts of the Microbiome in critically ill patients in the ICU after major and minor surgeries compared to baseline (preoperatively).

The purpose of this study is to assess the relationship between various PICU environmental factors (i.e. luminance, noise level, temperature) and sleep duration and quality, as recorded by caregivers and nursing staff.

The purpose of this study is to to collect urine samples to validate the NEPHROCLEARTM CCL14 Test in intensive care unit (ICU) patients with moderate to severe (Stage 2 or 3) acute kidney injury (AKI) as an aid in the risk assessment for developing persistent severe AKI (Stage 3 AKI lasting > 72 hours) within 48 hours of patient assessment.

The purposes of this study are to understand some key perspectives of patients and family members regarding the existing Get to Know Me board as a tool in humanizing the critical care environment, and to understand key perspectives of patients and families on the importance of humanizing the ICU and methods of doing so.

The purpose of this study is to measure the frequency and severity of posttraumatic stress symptoms, depressive symptoms, anxiety symptoms, and cognitive impairment following dismissal from the ICU and three months later. This study also seeks to identify which of the multiple ICUs at Mayo Clinic yields the highest incidence of post-intensive care syndrome so that a future study designed to provide a therapeutic intervention can be implemented in those areas with the greatest potential.

The investigators would like to determine if early administration of oral Midodrine in participants diagnosed with sepsis will impact blood pressures and decrease the need for and/or doses of intravenous pressor agents.

Study summary:

The overall plan for this study is to conduct qualitative interviews among 40 family members of patients who have been hospitalized in a coma. Subjects for this study will be recruited by local site P.I.s from intensive care units at the following 18 U.S. centers:

All interviews will be conducted virtually via video conferencing by study staff at the Yale School of Medicine and Massachusetts General Hospital. All study activities following the interviews, including data analysis and manuscript writing, will take place at the Yale School of Medicine and Massachusetts General Hospital. We expect ...

The purpose of this study is to investigate the association of decreased minute ventilation and greater incidence of oxygen arterial desaturation, hypercapneic or hypoxemic respiratory failure that requires high flow nasal oxygen therapy, non-invasive ventilation or re-intubation following cardiothoracic surgical procedures.
 

Collect hemodynamic data, such as heart rate, blood pressure, and cardiac output to help understand the effect of pre and post intubation.

The purpose of this study is to examine the period prevalence, independent risk factors and consequences of diarrhea in the ICU setting.

Over a third of those who survive critical illness suffer from symptoms of anxiety, depression, or post-traumatic stress disorder (PTSD) after leaving the intensive care unit (ICU). This is twice as high as the rates of PTSD in combat veterans. The strongest risk factor is memories of frightening experiences and delusions (something that is very common during critical illness, when patients feel that something is real when it is actually not). Patients can hear speech even when sedated, yet there is no systematic communication with the critically ill while they receive life-saving medical treatments. We think that lack of real-time communication ...

The purpose of this study is to evaluate whether post-ICU assessment predicts PICS at 3 months and to validate a screening tool to identify patients at risk for PICS.  

The purpose of this study is to evaluate the influenza vaccine effectiveness for preventing severe and life-threatening influenza-associated illness in children 6 months to 17 years of age.

The purpose of this study is to compare a standard steroid dosing algorithm to a novel biomarker-tailored steroid dosing algorithm for patients receiving corticosteroids for community acquired pneumonia.  Patients with severe community acquired pneumonia may benefit from adjunctive corticosteroid therapy. The optimal patient selection, dosing and duration of steroids is unknown.

The purpose of this study is to assess the ability of Non-invasive near-infrared spectroscopy (NIRS) as compared to Licox to detect regional changes in brain tissue oxygenation, and to compare changes in management based on data derived from monitoring.

The purpose of this study is to develop a protocol to frame the frequency and duration of neurological checks of patients in the Neuro Critical Care Unit.

The primary purpose of this study is to assess and describe the contributing sources of discomfort(s) experienced by ICU patients utilizing the Discomforts Perceived by ICU Patients instrument, a modified version of the Inconforts des Patients de REAnimation questionnaire (IPREA).

The purpose of this study is to evaluate the effectiveness of a seven-day slow-tempo music intervention on the primary outcome of delirium/coma free days among mechanically ventilated, critically ill older adults.

Critically ill older adults admitted to the intensive care unit (ICU) are at a higher risk to develop delirium, which predisposes them to longer lengths of ICU and hospital stay, increased in-patient mortality, and higher risk of new acquired cognitive impairment and dementia. Music listening is a non-pharmacological intervention that holds potential to decrease ICU delirium.

Endotracheal intubation (ETI) is a potentially life-threatening procedure for critically ill patients and major severe complications such as severe hypoxia, cardiovascular collapse and cardiac arrest are common. Despite the high risk of the procedure, different interventions lack high-quality evidence and the investigators hypothesize that a heterogeneous practice among different centres and geographical areas may be found. The investigators designed a large international observational study aiming at prospectively collecting data on the current impact of ETI-related adverse events and current airway management practice in critically ill patients. Investigators will collect data on all consecutive in-hospital (intensive care unit, emergency department and ...

As a part of the COVID-19 pandemic, Mayo Clinic Florida is utilizing remote monitoring technology to monitor non-ICU patients in order to identify patients who will need the ICU and prevent crashing patients on the floor. MCF is using approved InTouch video and Biofourmis remote vital sign monitoring technology, both used by Mayo Clinic in other capacities. This study will not be a study of the efficacy or the accuracy of these devices as they are already incorporated as standard of practice. This study will assess the reduction of on floor crashing patients, quality of care, and satisfaction of providers ...

The purpose of this study is to raise awareness of and actively address patient physical mobilization needs throughout admission to the ICU, and assess the impact this has on patient quality of care.

The purposes of this study are to to determine the physical, cognitive, emotional, and social health outcomes and trajectory of recovery in a population of children post-critical illness, to determine the baseline health, presenting problem, and PICU factors associated with impaired physical, cognitive, emotional, and social outcomes among PICU survivors, and to determine the emotional and social health outcomes in parents and siblings of PICU survivors. Our primary goal is to explicate the impact of pediatric critical illness over a two-year period of time to guide future intervention research to optimize child and family outcomes. Our overall goal is to improve ...

The purpose of this study is to test the feasibility of a psychotherapeutic intervention for critically ill patients in intensive care units. The intervention is named Early Psychological Support for the Critically Ill (EPSCI).

The purpose of this study is to compare the percentage of time sedation depth is maintained within the target range, in absence of rescue sedation, as assessed according to the RASS scale, in isoflurane- vs propofol-treated patients.

The purpose of this trial is to compare the effectiveness of psychological support based on positive suggestions (PSBPS) vs. usual care on mental health morbidity and cognitive function in survivors of critical illness.

Aims:

1.To assess the accuracy of limited ultrasonography of internal jugular vein (IJV), subclavian vein (SV), and inferior vena cava (IVC) for non-invasive measurement of central venous pressure (CVP)

The objective of this project is to refine and test a behavioral intervention to be administered in parallel with medical treatment in the ICU.

This study aims to assess the experiences of lesbian, gay, bisexual, transgender, and/or queer (LGBTQ) patients who have been admitted to the intensive care unit and to identify any unique stressors or heteronormative biases that are faced by LGBTQ patients in the course of an admission to the ICU. Most patients who are admitted to the ICU require a surrogate decision maker to communicate on their behalf at some point in their stay. However there is wide variety in legal standards for who has the authority to act as a surrogate decision maker if the patient has not designated one already. Fifteen ...

The purpose of this study is to observe and characterize the pharmacokinetics of anti-pseudomonal beta-lactam antibiotics (cefepime, piperacillin/tazobactam, meropenem) in critically ill adults..

The overall goals of this pilot study are to: (1) describe pharmacogenomics (PGx) testing results and identify PGx variants that may inform treatment regimens and symptom management in cardiac surgical patients with an ICU stay, and (2) describe cardiac critical care team members’ awareness and attitudes towards the applications of pharmacogenomics testing results for their practice before and after completion of a PGx education module.
 

The purpose of this study is to test the feasibility, compliance, and impact of synchronous physician engagement for patients (adult and pediatric) being cared for in the prehospital arena (either 911 or community paramedic follow up calls) and interfacility transports. 

The purpose of the study is to validate wearable device monitoring with standard ICU/stepdown patient vital signs monitoring especially heart rate, telemetry, respiratory rate, blood pressure, and pulse oximetry.

The purpose of this study is to evaluate the effect of a pre-ICU admission simulation session on post-operative delirium in the elective cardiothoracic surgical population while in the intensive care unit.

The primary purpose of this study is to assess the feasibility of performing lung and kidney and lung ultrasound elastography among patients with critical illness from different etiologies that could be associated with volume overload.

The purpose of this study is to determine if cytochrome P450 (CYP) enzyme family variants alter the body's metabolism of nimodipine after Aneurysmal Subarachnoid Hemorrhage (aSAH), and if actual levels of nimodipine correlate with clinical events and patient outcomes.

The purpose of this study is to evaluate if clazosentan (on top of normal routine medical care) can reduce the risk of developing complications related to cerebral vasospasm and permanent brain damage as compared to normal routine medical care alone.